The Scots had been knocked out of their World Cup play-off semi-final by the Ukrainians at Hampden Park in June.
Steve Clarke’s facet then suffered a dispiriting 3-0 Nations League defeat by Republic of Ireland, both facet of anticipated wins over Armenia.
Scotland will now need to rally in their three quick-fire games this worldwide break and declare top spot in Group B1.
They are currently second in the group forward of two matches against Ukraine both facet of a conflict against Ireland.
Scotland v Ukraine: How to follow
This Nations League Group B1 tie will take place on Wednesday, September 21.
It is taking place at Hampden Park in Glasgow and will kick off at 7:45pm.
The match will be proven on free-to-air tv and will be on ITV 4 from 7pm.
You may also live stream it totally free through the ITV web site.
talkSPORT will have updates from Scotland all through the night whereas talkSPORT.com will be working a live weblog.
To tune in to talkSPORT or talkSPORT 2 by way of the web site, click HERE for the live stream. You may also hear through the talkSPORT app, on DAB digital radio, by way of your sensible speaker and on 1089 or 1053 AM.
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Scotland v Ukraine: Team news
Scotland will be with out captain Andy Robertson after the Liverpool star suffered a knee injury in the Champions League.