He died in hospital hours after the collision at 1.30pm on Sunday in Gale Street, Dagenham.
Scotland Yard said the driving force of the car stopped at the scene and hasn’t been arrested.
A family buddy told The Standard: “I knew Joe, really close in our family we looked after him and looked out for him.
“He was always at our house and family gatherings.
“He is the sweetest boy, funny and very cheeky. I’m really going to miss his little freckly face. I’m truly heartbroken that he is gone so soon.
“I always told him to stay out of trouble and be a good boy.”
His friends carried out a experience out in his reminiscence at the spot the place the crash took place.
Joe’s social media profiles present him dancing at Prom evening, celebrating his last day of college and posts searching for building work. He additionally performs stunts on his bicycle in the native area. One of his last posts was an emotional reunion along with his father.
A witness to the aftermath of the crash said: “I can’t imagine the pain his family and friends are in. I can only hope his last moments weren’t painful.”
A Scotland Yard spokesman said: “Police were called to reports of a collision between a car and a moped in Gale Street, Dagenham.
“The rider of the moped – a 16-year-old boy – was taken to hospital. Sadly he died at hospital later that day.
“The boy’s family have been informed and will be supported by specialist officers.”