The fire at the Zeenat Supermarket in Alum Rock Road, Saltley, is lively and has unfold to flats above the shop.
West Midlands Fire Service said Thornton Primary School had been saved safe.
Seventy-nine firefighters have been at the scene through the top of the incident, with 12 fire engines and 5 brigade response autos.
There are a number of highway closures together with St Agatha’s Road, Alum Rock railway bridge, Woodhall Road, Bankdale Road, Thornton Road, Washwood Heath Road, Chetwyn Road, Alum Rock Road and Beanie Lane.
Investigations are being carried out to decide the trigger of the fire.
There have been no reported injuries.